TABLE 6.
Mean arterial pressure (MAP) and echocardiographic results in a subset of male control db/db + and diabetic db/db mice.
| db/db+ (N = 7) | db/db (N = 7) | p | |
| MAP (mmHg) | 73 ± 5 | 68 ± 2 | 0.38 |
| Heart rate (min–1) | 400 ± 17 | 340 ± 11 | 0.01* |
| Ejection time (ms) | 54.8 ± 2.8 | 65.2 ± 2.8 | 0.02* |
| Duration of diastole (ms) | 96.6 ± 4.6 | 112.4 ± 5.8 | 0.05 |
| p-wave duration (ms) | 13.5 ± 0.7 | 14.7 ± 0.8 | 0.26 |
| PR-interval (ms) | 50.7 ± 1.5 | 58.0 ± 1.5 | 0.01* |
| QT interval (ms) | 50.5 ± 1.5 | 64.0 ± 3.0 | 0.001* |
| QTc (ms) | 41.2 ± 1.3 | 48.0 ± 1.4 | 0.004* |
| LVPWd (mm) | 1.01 ± 0.07 | 1.11 ± 0.08 | 0.39 |
| LVPWd/TL (mm/cm) | 0.57 ± 0.04 | 0.67 ± 0.05 | 0.14 |
| LVPW thickening (%) | 61.4 ± 8.1 | 37.8 ± 2.2 | 0.03* |
| LVIDd (mm) | 3.59 ± 0.09 | 3.92 ± 0.09 | 0.03* |
| LVIDd/TL (mm/cm) | 2.02 ± 0.05 | 2.36 ± 0.05 | <0.001 |
| LVaread (mm2) | 8.89 ± 0.37 | 11.2 ± 0.45 | 0.002* |
| LV aread/TL (mm2/cm) | 5.00 ± 0.21 | 6.72 ± 0.27 | < 0.001* |
| Fractional foreshortening (%) | 42.3 ± 3.0 | 37.5 ± 1.9 | 0.20 |
| Ejection fraction (%) | 79.8 ± 3.1 | 75.1 ± 2.1 | 0.23 |
| Fractional area change (%) | 65.7 ± 2.5 | 58.8 ± 2.9 | 0.10 |
| Aorta IDd (mm) | 1.28 ± 0.05 | 1.27 ± 0.03 | 0.90 |
| Aorta IDd/TL (mm/cm) | 0.72 ± 0.03 | 0.72 ± 0.02 | 0.90 |
| Circumferential strain (%) | 23.1 ± 2.4 | 17.8 ± 4.3 | 0.30 |
| Aortic Vmax (mm/s) | 1008 ± 110 | 655 ± 76 | 0.02* |
| Aortic Vmean (mm/s) | 581 ± 63 | 379 ± 43 | 0.02* |
| Stroke volume (mm3) | 29.2 ± 2.5 | 29.7 ± 3.4 | 0.91 |
| Stroke volume/TL (mm3/cm) | 16.4 ± 1.43 | 16.7 ± 1.92 | 0.91 |
| Cardiac output (ml/min) | 11.5 ± 0.7 | 10.0 ± 1.1 | 0.28 |
| Cardiac output/TL (ml/min/cm) | 6.46 ± 0.39 | 5.63 ± 0.62 | 0.28 |
BM: body mass, d: end-diastole, ID: inner diameter, LV: left ventricle, PW: posterior wall, TL: tibia length, V: velocity. The values are means ± SEM. * P < 0.05, versus db/db+ (Student’s t-test).