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Schematic representation of the KLK6 self-regulation and the major effects of it functions on brain physiology. KLK6 is released by glial and neuronal cells to cleave ECM components and proteinase-activated receptors (PARs) which are important steps in the inflammatory response during the pathogenesis of neurodegenerative diseases. ECM, extracellular matrix; BBB, blood-brain barrier; CNS, central nervous system.
