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. 2020 Apr 3;82(6):804–808. doi: 10.1292/jvms.20-0026

Table 2. Human epidermal growth factor receptor 2 scoring methods proposed by the American Society of Clinical Oncology/College of American Pathologists.

Score Description
3+ Circumferential membrane staining that is complete, intense, and in >10% of tumor cells

2+ Circumferential membrane staining that is incomplete and/or weak/moderate and in >10% of tumor cells
or
Complete and circumferential membrane staining that is intense and in <10% of tumor cells

1+ Incomplete membrane staining that is faint/barely perceptible and in >10% of tumor cells

0 No staining observed
or
Membrane staining that is incomplete and is faint/barely perceptible
and
in <10% of tumor cells