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. 2020 Jun 23;14:167. doi: 10.3389/fncel.2020.00167

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Copyright © 2020 Slaoui Hasnaoui, Arsenault, Verdier, Obeid and Kolta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Responses elicited in trigeminal motoneurons upon stimulation of dorsal NVsnpr in mice. (A) top: schematic drawing of the brainstem slice preparation and the experimental conditions used. Bottom: example of a multiphasic EPSP recorded in the NVmt following electrical stimulation in the dorsal NVsnpr. Responses to 10 single pulses are shown. Inset: average trace of 10 EPSPs still shows the multiphasic component. (B) Depolarization does not reveal a reversal of the response. With depolarization, the stimulation elicited an action potential (Top trace, truncated). (C) This EPSP followed stimulation of 40 Hz. (D) Train of repetitive stimulations (500 ms 40 Hz) in the dorsal NVsnpr causes a long-lasting increase in the frequency of spontaneous PSPs in the recorded motoneuron. (E) Train of repetitive stimulations (500 ms 40 Hz) in the dorsal NVsnpr causes action potentials firing in the recorded motoneuron that seems to emerge from the summation of the increased spontaneous PSPs. (F) Example of a short-latency action potential (middle) elicited in the motoneuron by electrical stimulation in the dorsal NVsnpr. Hyperpolarization does not reveal an underlying postsynaptic potential (PSP; bottom) and firing preceding the stimulation causes failure (top). (G) High-frequency stimulation (166 Hz) reveals an inconsistency in latency and amplitude of the spike suggesting direct activation of the recorded motoneuron. (H) Extracellular injection of biocytin in NVmt reveals the dendritic processes of MNs extending into dorsal NVsnpr. Abbreviations: Stim, stimulation; NVsnpr, trigeminal main sensory nucleus; NVmt, trigeminal motor nucleus.