Table 3. Enrichment analysis of gene ontologies for the prognostic factors; Top five relevant molecular functions and regulating miRNA families are presented.
| Molecular Functions | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| - | ID | Name | Source | p Value | FDR B&H | FDR B&Y | Bonferroni | Genes from Input | Genes in Annotation |
| 1 | GO:0004364 | glutathione transferase activity | NA | 1.604e-16 | 7.380e-15 | 3.260e-14 | 7.380e-15 | 6 | 34 |
| 2 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups | NA | 8.095e-15 | 1.862e-13 | 8.223e-13 | 3.723e-13 | 6 | 63 |
| 3 | GO:0005254 | chloride channel activity | NA | 2.723e-6 | 3.803e-5 | 1.680e-4 | 1.253e-4 | 3 | 81 |
| 4 | GO:0015108 | chloride transmembrane transporter activity | NA | 4.001e-6 | 3.803e-5 | 1.680e-4 | 1.841e-4 | 3 | 92 |
| 5 | GO:0005253 | anion channel activity | NA | 4.134e-6 | 3.803e-5 | 1.680e-4 | 1.902e-4 | 3 | 93 |
| Regulating miRNAs | |||||||||
| - | ID | Name | Source | p Value | FDR B&H | FDR B&Y | Bonferroni | Genes from Input | Genes in Annotation |
| 1 | hsa-miR-122:mirSVR highEffct | hsa-miR-122:mirSVR conserved highEffect-0.5 | Micro RNA.org | 2.015e-5 | 7.938e-3 | 5.753e-2 | 1.588e-2 | 3 | 607 |
| 2 | hsa-miR-618:mirSVR highEffct | hsa-miR-618:mirSVR nonconserved highEffect-0.5 | Micro RNA.org | 1.124e-4 | 2.210e-2 | 1.602e-1 | 8.859e-2 | 3 | 1083 |
| 3 | hsa-miR-425*:mirSVR highEffct | hsa-miR-425*:mirSVR nonconserved highEffect-0.5 | Micro RNA.org | 1.403e-4 | 2.210e-2 | 1.602e-1 | 1.105e-1 | 2 | 188 |
| 4 | hsa-miR-518f:mirSVR highEffct | hsa-miR-518f:mirSVR nonconserved highEffect-0.5 | Micro RNA.org | 2.264e-4 | 2.739e-2 | 1.985e-1 | 1.784e-1 | 2 | 239 |
| 5 | hsa-miR-518c:mirSVR highEffct | hsa-miR-518c:mirSVR nonconserved highEffect-0.5 | Micro RNA.org | 2.994e-4 | 2.949e-2 | 2.137e-1 | 2.359e-1 | 2 | 275 |
Abbreviations: GO=Gene Ontologies; FDR=False Discovery Rate; B&H: Benjamini–Hochberg; B&Y: Benjamini–Yekutieli.