Table 3. Substrates of p38 group members – transcriptional regulators.

	Substrate	Kinase	Function	References
Chromatin remodeling regulators	BAF60c	p38α, p38β	Activates transcription of MyoD- target genes	Simone C et al., Nat Genet, 2004 109 Forcales SV et al., EMBO J, 2012 110
	RNF2	p38α	Modulates gene expression and histone 2B acetylation	Rao PS et al., Proteomics, 2009 124
	EZH2	p38α	Promotes cytoplasmic localization	Anwar T et al., Nat Commun, 2018 111
	dAFF2	p38α, p38β	Disrupts heterochromatin formation	Seong K-H et al., Cell, 2011 112
Other regulators	CRTC2	p38α	Enhances nucleocytoplasmic transport and represses transcription activity	Ma H et al., Mol Cell Biol, 2019 125
	E47	p38α, p38β	Enhances the formation of MyoD/ E47 heterodimers	Page JL et al., J Biol Chem, . 2004 126 Lluís F et al., EMBO J, 2005 127
	HBP1	p38α	Increases protein stability and represses transcription	Xiu M et al., Mol Cell Biol, 2003 128
	p18(Hamlet)	p38α, p38β	Increases protein stability and enhances transcription	Cuadrado A et al., EMBO J, 2007 129
	PGC-1α	p38α, p38β	Increases protein stability and enhances transcription	Puigserver P et al., Mol Cell, 2001 130
	Rb1	p38α, p38γ	Induces Rb degradation and cell death; suppresses Rb activity and promotes the G0-to-G1 transition	Delston RB et al., Oncogene, 2011 131 Tomás-Loba A et al., Nature, 2019 14
	SRC-3	p38α	Induces SRC-3 degradation and suppresses RARα-dependent transcription	Giannì M et al., EMBO J, 2006 132

CRTC2, CREB-regulated transcription coactivator 2; HBP1, HMG-box transcription factor 1; PGC-1α, peroxisome proliferator-activated receptor gamma co-activator 1 alpha; RAR, retinoic acid receptor; RNF2, ring finger protein 2.