Table 1.

Levels of SN38 in blood, tumor and normal organs after 1 dose of CPT-11 or SN38-TOA NPs

SN38	Blood (ng/ml)		Tumor (ng/g)		Liver (ng/g)		Spleen (ng/g)		Lung (ng/g)		Kidney (ng/g)
levels	CPT-11	SN38-TOA NP	CPT-11	SN38-TOA NP	CPT-11	SN38-TOA NP	CPT-11	SN38-TOA NP	CPT-11	SN38-TOA NP	CPT-11	SN38-TOA NP
4 hrs	8 (± 5)	4537(± 978)	147 (± 26)	383 (± 18)	1245 (± 101)	169965 (± 13524)	56 (± 8)	122691 (± 26283)	38 (± 16)	1710 (± 1328)	421 (± 81)	1289 (± 378)
24 hrs	<1	221 (± 8)	<10	193 (± 17)	201 (± 1)	126266 (± 8573)	5(± 5)	1262239 (± 18376)	5(± 4)	1976 (± 497)	13 (± 4)	1171 (± 335)
72 hrs	<1	25 (± 10)	<10	102 (± 18)	6 (± 6)	106890 (± 13106)	4(± 5)	110360 (± 31374)	<2	1445 (± 413)	6 (± 11)	664 (± 424)