Table 1.
MDR-TB cascade of care data sources and estimations, Madagascar, 2017
| Cascade step | Methods/data source | References | TB all forms | Presumptive MDR-TB | MDR-TB |
|---|---|---|---|---|---|
| n (95% CI) | n (95% CI) | n (95% CI) | |||
| 1. Prevalent cases |
• WHO • National drug resistance survey • National reference laboratory data • NTP case notification data |
[1, 2, 22, 23] | 61,880 (40,040–88,400) | 3646 (2258–5437) | 341 (61–913) |
| 2. Reached diagnostic and treatment centre |
• Country tuberculosis guidelines • Diagnostic literature • Locally assessed sensitivity of sputum microscopy and GeneXpert MTB/RIF • National reference laboratory data • NTP case notification data |
[17, 19, 20, 23–25] | 51,419 (46,744–57,250) | 3563 (3197–4046) | 224 (170–330) |
| 3. Diagnosed |
• National reference laboratory data • NTP case notification data |
[23, 26] | 35,339 (35,124–35,570) | 2485 (2443–2540) | 24 (22–27) |
| 4. Registered for treatment | • NTP clinical management data | [26] | 32,427 (−) | 2257 (−) | 18 (−) |
| 5. Cured or treatment completed | • NTP clinical management data | [26] | 28,178 (−) | 1852 (−) | 8 (−) |
| 6. Recurrence-free survival |
• NTP clinical management data • Clinical TB literature |
[26, 27] | 27,996 (27,774–28,108) | 1670 (1448–1782) | 8 (−) |
The cascade of care steps with references and total number of cases. Presumptive MDR-TB cases are included in TB all forms; MDR-TB cases are included in presumptive MDR-TB cases
CI confidence interval, MDR-TB multidrug-resistant tuberculosis, MTB/RIF Mycobacterium tuberculosis/rifampicin, NTP national tuberculosis control programme, WHO World Health Organization