Fig. 4.

Simultaneous administration of TLR2 agonist and miR146a mimics efficiently protect mice against OVA-induced allergic asthma. a Schematic diagram of the experimental protocol. The doses of Pam3CSK4 and miR146a mimics were 0.1 mg/kg and 1 mg/kg, respectively. b Eosinophils in CD45+ cells in BALF. c Eosinophils in BALF. d Histologic sections of lungs from each group were analyzed by H&E. Pictures show representative samples of 6 mice/group. Scale bar = 100 μm. e Histological scores for assessment of lung injury were shown. Data represent means ± SD. WT, wide type mice without OVA-induced allergic asthma. n = 6, *p < 0.05, **p < 0.005, ***p < 0.001