TABLE 1.

Pharmacological effects of agents on FUS-stimulated Ca²⁺ dynamics in PC-3 cells.

Agents	Target effect	Ca2+ Response
External Ca2+ influx
BTP2	CRAC inhibitor, Blocks Ca2+Influx	Normal, Supplementary Figure S3
SKF96365	TRP antagonist, Blocks Ca2+Influx	Normal, Supplementary Figure S3
Intracellular Ca2+ release
Carbenoxolone	PANX1 inhibitor	Blocked, Supplementary Figure S4
Flufenamic acid	PANX1, CX43 inhibitor	Blocked, Supplementary Figure S4
Probenecid	PANX1 inhibitor	Blocked, Supplementary Figure S4
10Panx1	PANX1 inhibitor	Partly Blocked, Figure 3
Xestospongin C	IP3Rs inhibitor	Partly Blocked, Figure 3
Intercellular Ca2+ wave propagation
Apyrase	Extracellular ATPase	Blocked, Figure 7
Suramin	P2 purinergic receptor antagonist	Blocked, Figure 7
PPADS	P2 purinergic receptor antagonist	Blocked, Figure 7
AZ11645373	Selective P2X7 inhibitor	Normal, Supplementary Figure S3
MRS2179	Selective P2Y1 antagonist	Normal, Supplementary Figure S3