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. 2020 Feb 3;107(6):1296–1311. doi: 10.1002/cpt.1729

Figure 3.

Figure 3

Establishing novel clinical experimental paradigm to demonstrate glucose responsive clearance mechanism. Upper figure: Simulations for insulin concentrations, insulin infusion rates, glucose concentrations, and glucose infusion rates for RHI study MK‐0000‐339 using the University of Virginia / Padova T1DM metabolic simulation platform.25 Lower figure: steady‐state observations from RHI study MK‐0000‐339 26 on model predictions from MBMA analysis,24 confirming that the model‐based analysis of steady‐state clamp data performed well in predicting steady‐state RHI PK (pharmacokinetics) and PD (pharmacodynamics). GIR, glucose infusion rate; MBMA, model‐based meta‐analysis; PID, proportional integral differential; RHI, regular human insulin; T1DM, type 1 diabetes mellitus.