. Author manuscript; available in PMC: 2020 Aug 2.

Published in final edited form as: J Proteome Res. 2019 Jul 19;18(8):3032–3041. doi: 10.1021/acs.jproteome.9b00145

Table 3.

Non-compartmental pharmacokinetic analysis

PK parameter	Blood [SD]	Plasma [SD]	Blood/Plasma
C₀ [μg/mL]	32.3 [6.0]	50.0 [9.6]	0.65
C_max [μg/mL]	20.3 [5.6]	33.0 [9.1]	0.62
C_last [μg/mL]	0.59 [0.04]	0.81 [0.22]	0.72
AUC_last [μg · h/mL]	8.5 [2.6]	13.9 [4.6]	0.61
t_{1/2 initial} [min]	8.3 [0.41]	8.5 [0.7]	0.98
t_{1/2 terminal} [h]	2.8 [1.6]	1.8 [0.2]	1.56
AUC_infinity [μg · h/mL]	8.6 [2.6]	14.1 [4.7]	0.61
Clearance [L · kg/h]	0.52 [0.13]	0.33 [0.10]	1.60
MRT_last [h]	0.51[0.04]	0.47 [0.01]	1.08
V_ss [L/kg]	0.29 [0.09]	0.16 [0.05]	1.76

C₀, extrapolated concentration at time 0; C_max, concentration observed 5 min post-injection; C_last, concentration observed 3 h post-injection; AUC_last, area under the curve between 0–3 h; t_{1/2 initial}, half-life during first 30 minutes; t_{1/2 terminal}, half-life observed between 1 h and 3 h; AUC_infinity area under the curve extrapolated to infinity; MRT_last, mean residence time observed between 0–3 h; V_ss, steady state volume of distribution