Figure 2.

Neutralizing antibody titer to a virus containing a reconstructed pentameric complex, stratified by cohort. Each black dot indicates the result for an individual patient. Boxes represent first to third quartiles; lines within boxes, medians; whiskers, minimum and maximum values; and dotted line, cutoff for quantitation. Projected median inhibitory concentration (IC₅₀) values <5 that showed evidence of some neutralizing capacity at only the highest plasma dilutions were considered to have a detectable but not quantifiable response and were scored as 2.5. If there was no evidence of any neutralization even at the highest concentrations of plasma, the result was shown as 0. Abbreviations: AP, antiviral prophylaxis; Ctrl+, cytomegalovirus (CMV)–seropositive healthy controls; Ctrl−, CMV-seronegative healthy controls; PET, preemptive therapy; R+, CMV-seropositive transplant recipients who received AP as controls.