Figure 4.

Multifunctional CD8 (A, B) and CD4 (C, D) cytomegalovirus (CMV)–specific T-cell responses to phosphoprotein 65 (pp65) (A, C) and immediate early protein 1 (IE-1) (B, D) 3 months after transplantation. Each black dot represents results from an individual patient, and whiskers represent minimum and maximum values. A multifunctional T-cell response was defined as expressing ≥2 cytokines or degranulation markers. Abbreviations: AP, antiviral prophylaxis; PET, preemptive therapy; R+, CMV-seropositive transplant recipients who received prophylaxis.