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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: J Physiol. 2020 Feb 11;598(8):1475–1490. doi: 10.1113/JP279161

Table 3.

Ventilatory, metabolic and cardiovascular variables at maximal exercise

Controls High-affinity variants
Normoxia Hypoxia Normoxia Hypoxia Hb type Inspirate Interaction
⩒A (L·min−1) 80±15 80±24 74±17 73±17 NS NS NS
⩒E (L·min−1) 96±20 89±19 91±15 93±17 NS 0.01 <0.001
⩒O2 (L min−1) 2.65±0.6 2.32±0.5 2.35±0.6 2.25±0.5 NS <0.001 0.002
⩒O2 (mL·kg−1·min−1) 33±7 29±6 28±7 27±6 NS <0.001 0.002
⩒CO2 (L·min−1) 2.97±0.6 2.60±0.6 2.67±0.6 2.53±0.5 NS <0.001 <0.001
RER 1.12±0.05 1.11±0.06 1.14±0.05 1.13±0.06 NS NS NS
⩒E/⩒O2 37±6 39±6 40±7 42±7 NS <0.001 NS
⩒E/⩒CO2 33±5 35±5 35±5 37±5 NS <0.001 NS
Peak power (W) 173±49 152±42 132±34 127±31 NS <0.001 0.001
VO2/W (mL·W−1) 12.3±1.0 11.8±1.2 13.5±2.3 13.7±2.6 0.037 NS NS
HR (bpm) 176±13 173±13 183±12 181±10 NS 0.002 NS
MAP (mmHg) 131±20 131±17 142±23 140±25 NS NS NS

Values are mean±SD.; ⩒A, alveolar ventilation; ⩒E, expired minute ventilation; ⩒O2, oxygen uptake; ⩒CO2, carbon dioxide production; RER, respiratory exchange ratio; W, Watts; HR, heart rate; MAP, mean arterial pressure.