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. 2020 May 18;133(10):jcs243451. doi: 10.1242/jcs.243451

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© 2020. Published by The Company of Biologists Ltd

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Fig. 6. — Overexpression of ATX2 or RIN induces IPSGs. (A–J) Grayscale confocal micrographs of progenitor cells with elevated expression of (A) AGO1::FLAG, (B) ATX2::HA, (C) CAPR::FLAG::HA, (D) DCR2, (E) eIF4E::HA, (F) FMRP::HA, (G) LIN-28::FLAG::HA, (H) pABP::FLAG, (I) RIN::HA or (J) ROX8:: FLAG::HA. The stained epitope is underlined in each panel. Note that only the elevated expression of ATX2 and RIN causes aggregation of cytoplasmic granules. (K–R) Grayscale confocal images of progenitor cells with elevated expression of ATX2::HA stained for (K) AGO1, (L) DCR2, (M) eIF4E, (N) FMRP, (O) PABP, (P) ROX8 and (Q) Oligo-dT. Similar to what is seen with acute stress-induced IPSGs, stress granules induced by ATX2 overexpression contain multiple RBPs as well as mRNAs.