Skip to main content
. Author manuscript; available in PMC: 2020 Jun 30.
Published in final edited form as: Methods Mol Biol. 2017;1677:1–80. doi: 10.1007/978-1-4939-7321-7_1

Table 2.

Summary of GluN2B-selective modulators.

Activity at GluN1/2X (in μM)
Compound 2A 2B 2C 2D
Ifenprodil graphic file with name nihms-1600275-t0009.jpg IC50 39.5 0.114 29.1 75.9 [525]
CP-101,606 graphic file with name nihms-1600275-t0010.jpg IC50 NE 0.039 NE NE [85]
Ro 25–6981 graphic file with name nihms-1600275-t0011.jpg IC50 52 0.009 - - [365]
EVT-101 graphic file with name nihms-1600275-t0012.jpg IC50 - 0.012 - - [281]
-

denotes not determined and NE denotes no effect at the highest concentrations evaluated. Unless otherwise stated (also denoted by †), the potency (i.e. half maximally inhibiting concentration) was determined using two-electrode voltage-clamp experiments with Xenopus oocytes.