Estradiol (E2) and Estrogen Receptor (ER) Agonist Regulation of Female versus Male Hypothalamic Astrocyte Glycogen Metabolic Enzyme and ER Protein Expression. Tables on right (female) and left (male) sides denote minimum E2 dosages that significantly augmented astrocyte GS, GP, ERα, ERβ, GPER, and pAMPK protein expression in each sex. Sex dimorphic effects of E2 and individual ER agonists on astrocyte ER variant profiles and glycogen content are presented below illustrations of female versus male astrocytes.