Figure 1.

Serum NS1 IgG concentrations in recipients of TAK-003. Subject-matched serum samples from placebo or TAK-003 recipients that were either dengue virus (DENV)-naive or DENV-preimmune, obtained at different times pre- or postvaccination, were tested using the DENV-2 NS1 IgG indirect enzyme-linked immunosorbent assay. The OD₄₀₅ values were plotted against log₁₀ dilution factor. Dilution factors were interpolated for each sample at OD₄₀₅ of 0.5, and concentration was calculated relative to the assigned EC₅₀ of the reference standard/DENV-positive serum. Statistical analyses were performed using 1-way ANOVA, with Tukey multiple comparison. ****, P < .0001; *, P = .025; ns, not significant. Abbreviations: LLOQ, lower limit of quantitation.