Figure 2.

Cross-reactivity of the TDV-2 NS1 IgG response. Pre- and postvaccination (day 0 and day 120, respectively) serum samples from dengue virus (DENV)-naive or DENV-preimmune TAK-003 recipients were tested in the NS1 IgG indirect enzyme-linked immunosorbent assay using NS1 antigen from DENV-1, -2, -3, or -4. The concentration of NS1 IgG calculated relative to the DENV-positive control serum is plotted against times postvaccination for each serotype. Statistics were performed using 1-way ANOVA, with Sidak multiple comparison. ****, P < .0001; ns, not significant. Abbreviations: LLOQ: lower limit of quantitation