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. 2020 Feb 7;61(2):3. doi: 10.1167/iovs.61.2.3

Figure 1.

Figure 1.

KO of EMP2 does not affect retinal histologic structure. (A) WT normoxia (first row), Emp2 KO normoxia (second row), WT hyperoxia (third row), and Emp2 KO hyperoxia (fourth row) retinal sections. The dashed line indicates a representative area measured. Hyperoxia treated animals were exposed from P7 to P12, and P7 animals before hyperoxia exposure are not shown. Scale bars represent 100 µM. (B) Quantitation of retinal thickness. No differences in retinal thickness between WT and Emp2 KO mice were observed from quantitation of 20X images at each individual time point (P12, P17, and P21). Data are presented as the mean ± SEM (N = 6−9 per group). (C) Retinal thickness corrected for body weight in OIR was normalized relative to normoxia retinal thickness corrected for body weight at the same gestational age. Decreased retinal thickness was observed in Emp2 KO mice compared with WT mice at P17 when normalized for body weight (P = 0.025 by Student's t-test; N = 4−7/group). GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium; CH: choroid; S, sclera.