Figure 1.

Relationship between significant HLA alleles and CD8 (A) or CD4 (B) activation. Significant (P ≤ .05) associations of HLA alleles with percentage of CD8⁺CD38⁺DR⁺ (A) and log percentage of CD4⁺CD38⁺DR⁺ (B) T cells in multivariate linear models, with adjustments for race/ethnicity, principal components, age, laboratory data source, antiretroviral therapy, human immunodeficiency virus load, and hepatitis C virus status. The β estimate (with 95% confidence interval) is shown for each allele. *P ≤ .01 after adjustment for multiple tests (false discovery rate, <0.10).