Table 3.
Association of CD4 T-Cell Activation Levels (Log of CD4+CD38+DR+) With HLA Alleles Among Human Immunodeficiency Virus–Infected Women Naive to Highly Active Antiretroviral Therapya
| Allele | β (95% CI), Log Scaleb | Mean Difference, Raw Scalec | P Value | FDRd |
|---|---|---|---|---|
| B*57:03 | −0.26 (−0.45 to −0.07) | −2.7 | .007 | 0.07 |
| C*12:03 | 0.25 (0.08–0.42) | 3.3 | .004 | 0.06 |
| DQA1*01:00 | −0.14 (−0.24 to −0.05) | −1.7 | .003 | 0.06 |
| DQB1*03:02 | 0.18 (0.05–0.31) | 2.3 | .005 | 0.06 |
| DQB1*06:03 | −0.24 (−0.41 to −0.08) | −2.6 | .003 | 0.06 |
| DRB1*13:01 | −0.25 (−0.39 to −0.11) | −2.7 | <.0004 | 0.03 |
Abbreviations: CI, confidence interval; FDR, false discovery rate.
aSample size of 580 women with a total of 1161 study visits. Samples with missing HLA data were imputed (see Supplementary Table 1 for percentage of data imputed by HLA type). The FDR was controlled at 0.10.
bThis value (β) is the difference in percentage of activated CD4 T cells in individuals with the allele as compared to individuals without the allele, estimated using generalized estimating equation models. Models were controlled for age, race, principal components, laboratory data source, antiretroviral therapy, human immunodeficiency virus RNA, and hepatitis C virus status.
cThe expected difference in mean percentage of activated CD4 T cells between individuals with and those without the allele (covariates at mean or reference level).
dFDR computed using the Benjamini and Hochberg method.