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Neutrophil-released factors in the tumor microenvironment. The neutrophils in the tumor microenvironment may facilitate cancer progression through secretion of proteases such as NE and CG, chemokines, and cytokines (which leads to the recruitment of other pro-tumor immune cells or T cell immunosuppression), together with the release of RNS/ROS. Neutrophils also facilitate cancer progression through formations of NETs
