Fig 2. Comparison of performance between ridge regression and elastic net.
Performance was evaluated on simulated ground truth using three metrics: root-mean-square error (RMSE) between true and estimated interactions, RMSE between true and estimated growth rates, and RMSE between true and estimated hold out trajectories for 5 samples per simulation replicate. Box plots describe the distribution in RMSE over 50 simulation replications. Significance is computed using the Wilcoxon signed-rank test (****: p < 10−4; ***:p < 10−3; **: p < 10−2; *: p < 0.05; ns: not significant).