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. 2020 Jun 10;8:574. doi: 10.3389/fbioe.2020.00574

Figure 1.

Figure 1

The augmented forward Euler scheme implemented in μbialSim. In each numerical integration step, first the FBA solutions are computed for all member species of the simulated microbiome. The new system state is then computed using obtained rates and the default time step size. If negative concentration values for biomasses or compounds occur, the time step size is reduced as required.