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. 2020 Jun 17;8:501. doi: 10.3389/fbioe.2020.00501

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Copyright © 2020 Greene, Sanchez-Tapia and Sontag.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Numerical solution of the optimal control problem with d = 0.05, α = 0.005, and the remainder of parameters as in Table 1. (A) Sensitive (x₁) and resistant (x₂) temporal dynamics. (B) Control structure of form YXu_pY. (C) Volume dynamics. Note that the trajectory remains on the line V = V_c for most times, with corresponding control u = u_p.