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. 2020 Jun 5;11:1010. doi: 10.3389/fimmu.2020.01010

Figure 2.

Figure 2

rP21 leads to increased production of NO, IFN-γ and IL-4 by myoblasts infected with the Y strain of T. cruzi, without causing the death of the parasite. (A) Infected or not (NI) myoblasts show a higher nitric oxide production when treated with rP21 or IFN-γ. (B) Supernatant of Y strain infected cells has higher levels of IFN-γ and IL-4 and lower levels of IL-10 when treated with rP21. (C) The ability of intracellular amastigotes recovered from rP21-treated myoblasts to differentiate into epimastigotes was not altered. Data are expressed as mean ± standard deviation of experiments performed in triplicate. Significant differences were determined using one-way ANOVA and Tukey's multiple comparisons test (a, b, c). Differences were considered significant when p < 0.05.