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Qualitative analyses of alterations in heart tissue.
| Groups | Inflammatory infiltrate | Tissue damage | Epicardium calcification | Nests |
|---|---|---|---|---|
| PBS Control | – | – | – | – |
| rP21 Control | – | – | – | – |
| PBS Infected - 106 | + + + | + + + | ++ | + + + |
| rP21 Infected - 106 | ++ | + | + | ++ |
| PBS Infected - 105 | ++ | + | – | + |
| rP21 Infected - 105 | + | + | – | – |
The rP21 treatment reduces cardiac inflammatory infiltrate, tissue damage, epicardium calcification and the number of amastigotes nests compared to infected control group.
