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. 2020 Jun 11;11:716. doi: 10.3389/fimmu.2020.00716

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Copyright © 2020 Stoler, Freytag, Orak, Unterwalder, Henning, Heim, von Bernuth, Krüger, Winkler, Eschenhagen, Seipelt, Mall, Foell, Kessel, Wittkowski and Kallinich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spontaneous secretion of IL-18, caspase-1, and S100A12 by neutrophils derived from MEFV mutation carriers and controls. Isolated neutrophils from healthy controls (filled circles, n = 5–7), healthy heterozygous MEFV mutation carriers (filled triangles, n = 6), FMF patients with compound heterozygous or homozygous mutations (open circles, n = 9), and patients with other chronic inflammatory and infectious diseases (open triangles, n = 7–22) were cultured without stimulation. Secretion of IL-18 (A), caspase-1 (B), and S100A12 (C) was assessed by ELISA in the supernatants at indicated time points. Note that values for S100A12 are represented on a logarithmic scale and in pg/ml. Values are given as median and interquartile ranges.