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. 2020 Jun 19;11:359. doi: 10.3389/fendo.2020.00359

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Copyright © 2020 Hou, He, Ma, Yang, Xu, Lam, Shui, Yang, Zhang, Qiang and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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General analysis of lipidomic profiles in the kidney cortex of diabetic nephropathy (DN) and normal rats. (A) Principal component analysis (PCA) of whole lipidome of the two groups. (B) Volcano plot of all lipid species detected in the two groups. Data are shown as ratios of DN/NC, false discovery rate (FDR) < 0.05, and fold change > 1.5 is highlighted. Heatmap analysis of (C) main lipid class, (D) overall enrichment of chain length for lipid species, and (E) overall quantification of unsaturated bonds for lipid species; n = 6 per group.