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. 2020 Jun 3;8:532. doi: 10.3389/fbioe.2020.00532

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Copyright © 2020 Saravanan, Zhang, Zhang, Xi and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Positron emission tomography (PET) brain images of a chronic AD patient (left) and a normal brain (right); (B) Aβ immunostaining of the homogenates of the hippocampus and overlying cortex obtained from aged non-transgenic mice (left) and transgenic (APP23:Gfap-luc) mice inoculated with purified transgenic (APP23) Aβ fibrils (right). (C) Negatively stained TEM of unstained, freeze-dried Aβ₁_–₄₂ fibrils. (D) The microscopic structure of Aβ₁₅_–₄₂ fibrils is shown in the ribbon diagram.