FIGURE 2.

In amyloid formation, flexible sequence fragments of an amyloid precursor protein undergo many structural changes that may cause toxicity, aggregation, and misfolding, which ultimately lead to several neurological disorders, as schematically shown in the upper panel of this figure. In the lower panel, the schematic diagram represents the studies performed by researchers from various disciplines to study Aβ peptides. Among the various methods used, such as sequence based, molecular dynamics simulation, physicochemical methods, etc., the machine learning method could be combined with these methods, providing a better understanding of the mechanism of Aβ peptide aggregation.