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. 2020 Jun 16;8:383. doi: 10.3389/fcell.2020.00383

FIGURE 2.

FIGURE 2

Network construction of ciRNA13761/DOCK1/novel-miR-3880/ELF2 axis. (A) Information of Wt and Mu psiCHECK2-ciRNA13761 Wt and Mu vectors design and relative luciferase activity when vectors were co-transfected with novel-miR-3880 or NC. (B) The efficiency of si-ciRNA13761. (C) The efficiency of pcDNA3.1#-ciRNA13761 and effects of novel-miR-3880 on pcDNA3.1#- ciRNA13761 efficiency. (D) Effects of novel-miR-3880 on ciRNA13761 expression. (E) The regulation of ciRNA13761 to novel-miR-3880 expression. (F,G) The regulation of ciRNA13761 and novel-miR-3880 to ELF2 mRNA and protein. (H,I) The efficiency of siELF2 at mRNA and protein levels. (J,K) Effects of ELF2 on ciRNA13761 and novel-miR-3880 expression; the existence of novel-miR-3880 could impair the expression of ciRNA13761 enhanced by ELF2 overexpression. (L–N) Effects of ELF2, novel-miR-3880 and ciRNA13761 on DOCK1 expression. (O) The efficiency of siDOCK1. (P–R) The regulation of siDOCK1 to ELF2, novel-miR-3880 and ciRNA13761.