TABLE 2.

The methods differences between literatures.

Methods	Literatures	Differences
The preparation of metal-hesperidin analogs complexes	Gao et al. (2018)	The product was prepared by an integrated separation reaction pathway, but the substrate was not a derivative of hesperidin.
	Chen and Zhu (2018)	The product purity of zinc-hesperidin complex prepared by solution coordination was lower than that prepared by separation and integration method.
	Carceller et al. (2019)	In this paper, GO was used to immobilize rhamnosidase for selective synthesis of citrus flavonoids prunin and naringenin, but no magnetic separation.
Biosynthesis pathway of hesperetin analogs	Koseki et al. (2008)	The study focused on the hydrolysis ability of extracted rhamnosidase to flavonoids and did not immobilize the enzyme.
	Yadav et al. (2012)	The enzymatic properties of α-L-rhamnosidase were studied after it was purified without immobilization, and hydrolyzed naringin, rutin and tangerine to liberate L-rhamnose.
	Patel et al. (2017)	Reduced GO-Fe3O4 was synthesized to support enzyme immobilization. Unlike the enzyme immobilized in my paper, and the immobilized material GO was reduced.
The immobilization by magnetic Fe3O4@GO	Fan et al. (2017)	A composite material (MIP@Fe3O4@GO) was used to simultaneously separate and enrich two alkaloids (evodiamine and rutaecarpine) in the extract of evodiae fructus.
	Hua et al. (2014)	The oxidative degradation characteristics of bisphenol A in a heterogeneous Fenton reaction catalyzed by Fe3O4/GO were studied. It is different from the application of the composite in my paper.