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. 2020 Jun 9;11:1164. doi: 10.3389/fimmu.2020.01164

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Copyright © 2020 Puértolas-Balint and Schroeder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Location of host defense peptide (HDP) expression along the mice intestine under normal physiological conditions. The antimicrobial activity is specific to each HDP class: bactericidal (red), bacteriostatic (green) and aggregation (blue). α-defensins can also be referred to as Defas in mice. C-type lectin regenerating islet-derived protein 3 gamma (Reg3γ); Angiogenin 4 (Ang4); secretory phospholipase A2 group IIA (sPLA2); cryptdin-related sequence peptides (CRS-peptide)s; Lipocalin-2 (Lcn2); Ly6/PLAUR domain containing 8 protein (Lypd8); zymogen granule protein 16 (ZG16); resistin-like molecule beta (RELMβ).