Table 1.
Influence of host defense peptides (HDP) on microbiota composition in in vivo studies.
| Host defense peptide treatment | Effect on SI microbiota (relative abundance) | Effect on fecal/colonic microbiota (relative abundance) | References |
|---|---|---|---|
| Transgenic expression of HD5 | ↑ Bacteroidetes ↓ Firmicutes |
NA | (9) |
| Mmp7−/− | ↑ Firmicutes ↓ Bacteroidetes |
NA | (9) |
| NA | No difference when compared to wild-type | (111) | |
| HD51−9 | ↑ Akkermansia and members of the Ruminococcaceae family ↓ Intestimonas from the Clostridiaceae family |
↓ Bacteroides and Lactobacillus genera ↑ Akkermansia spp. and Parasutterella |
(154) |
| Administration of HD5 | ↑ Bifidobacterium | ↑ Bifidobacterium and Alloprevotella
↓ Parabacteroides |
(17) |
NA, not available, was not investigated in the study. SI, small intestine.