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. 2020 Jun 17;11:1176. doi: 10.3389/fmicb.2020.01176

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Copyright © 2020 Leal, Campos, Rezende, Docena, Mendes-Marques, de Sá Cavalcanti, Wallau, Rocha, Cavalcanti, Veras, Alves, Andrade-Figueiredo, de Barros, de Almeida, de Morais, Leal-Balbino, Xavier and de-Melo-Neto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of other resistance genes associated with transposable elements found in the A. baumannii strains sequenced in this study. Green triangles are inverted terminal repeats of insertion sequences flanking resistance genes. Green boxes are genes related with the transposition process and red boxes are resistance and virulence genes. Tnp, transposase; Int, Integrase; and XerD, tyrosine recombinase. Further structures of selected resistance genes and associated TEs can be found in the Supplementary Figure S6. (A) The ampC (bla_ADC) gene and its upstream ISAba1. (B) The bla_OXA–169 gene with the identified upstream ISAba1. (C) The bla_OXA–72 gene with flanking genes and ISAba13 insertions. (D) The aph3 gene with flanking ISAba125 fragments. (E) The strB, strA and floR genes with associated ISVsa3 motifs. (F) The acc-6-lb-c and bcr-1 genes and their association with ISAba43. (G) The aadB and proximal genes in association with ISAba2 and IS1006.