Table 1.

Comparison of human KD to common murine models of KD.

	Human KD	CAWS	LCWE
Pathogenesis	Unknown	Superantigen	Superantigen
Etiology	Unknown	Candida albicans water soluble injection	Lactobacillus casei cell wall extract injection
Animal	Human	Mice	Mice
Arteritis	medium-sized, muscular arteries, includes epicardial coronary arteries	Targets elastic arteries, including aortic root	Elastic arteries, aortitis, proximal coronary arteritis, abdominal aorta dilatations.
Histology	Early neutrophils, mixed data on granulomas	Monocytes, macrophages, neutrophils	Granulomatous
Myocarditis	Subclinical, Tachycardia	Significant	Significant, CK-MB and troponin rise, late myofibrosis
Timing	Adventia/intima to pan vasculitis	Progresses from initial intima layer slowly to panvasculitis	np
Therapy that reduces coronary inflammation	IVIG shows efficacy, Cyclosporine A efficacious in higher risk individuals	TNF a blocks arteritis IVIG partially blocks arteritis IVIG timing influences effect	Diminished by IVIG, anti-TNFα, anti-IL-1
Long term findings	Unclear associations Limited pathologic samples, mixed reports	np	Atherosclerosis, myofibrosis

np, not published.