TABLE 3.
Risk of CV Event in HFrEF patients with multivariate Cox regression analysis.
| Variables | Model without CS |
Model with CS |
||||
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age, > 55 vs. < 55 years | 0.88 | 0.45–1.72 | 0.71 | 0.95 | 0.49–1.86 | 0.88 |
| Sex, female vs. male | 0.45 | 0.20–1.03 | 0.06 | 0.47 | 0.20–1.07 | 0.07 |
| BMI, kg/m2 | 1.0 | 0.98–1.09 | 0.25 | 1.04 | 0.98–1.1 | 0.19 |
| NYHA class, III-IV vs. I-II | 2.75 | 1.39–5.43 | <0.01 | 2.59 | 1.33–5.06 | 0.01 |
| LVEF% | 1.03 | 0.99–1.07 | 0.14 | 1.04 | 1.00–1.08 | 0.07 |
| eGFR, ml/min/m2 | 1.00 | 0.98–1.01 | 0.53 | 0.99 | 0.98–1.01 | 0.36 |
| NT-proBNP, Q4 vs. Q1 | 3.05 | 1.00–9.30 | 0.05 | 3.30 | 1.1–10.0 | 0.03 |
| CS, >1.9 vs. <1.9 | – | – | – | 1.93 | 1.07–3.48 | 0.03 |
CV, cardiovascular; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio; CI, confidence interval; eGFR, estimated glomular filtration rate; BMI, body mass index; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction.