FIGURE 2.

(A) Weight-normalized lymph flow rate (in ml/h/kg) at all lipid doses, and (B) Weight-normalized lymph flow rate (in ml/h/kg) at low lipid doses versus enteral lipid dose in mice, rats, dogs, and humans. (C) Allometric scaling of lymph flow rate (in ml/h) in the fasted state and after administration of low lipid doses of 8.4 mg/h/kg in humans and 18.1 mg/kg over 0–2 h in mice, rats and dogs. Mice and rats were intraduodenally infused with the lipid dose over 2 h, dogs were administered a single oral lipid dose and human patients were continuously infused with enteral nutrition at different rates. The lymph flow rates in mice, rats and dogs are the mean hourly rate over an 8 h lymph collection period whereas in human patients the lymph flow rates are the mean for 1 h collection periods completed twice daily. Data are mean ± SEM for n = 3–4 for mice, rats, and dogs and mean ± SEM for 19, 9, and 6 replicates from n = 3, 3, and 2 human patients administered 0, 20, and 80 ml/h enteral nutrition, respectively. Data for mice, rats and dogs are from published studies (Trevaskis et al., 2013) although this analysis has not previously been published.