FIGURE 3.

(A) Weight-normalized lymph triglyceride (TG) transport rate (in mg/h/kg) at all lipid doses, and (B) Weight-normalized lymph TG transport rate (in mg/h/kg) at low lipid doses versus enteral lipid dose in mice, rats, dogs, and humans. (C) Allometric scaling of lymph TG transport rate (mg/h) in the fasted state and after administration of a low lipid dose of 8.4 mg/h/kg in humans and 18.1 mg/kg over 0–2 h in mice, rats and dogs. Mice and rats were intraduodenally infused with the lipid dose over 2 h, dogs were administered a single oral lipid dose and human patients were continuously infused with enteral nutrition at different rates. The lymph TG transport rates in mice, rats, and dogs are the mean hourly rate over an 8 h lymph collection period whereas in human patients the lymph TG transport rates are the mean for 1 h collection periods completed twice daily. Data are mean ± SEM for n = 3–4 for mice, rats and dogs and mean ± SEM for 19, 9, and 6 replicates from n = 3, 3, and 2 human patients administered 0, 20, and 80 ml/h enteral nutrition, respectively. Data for mice, rats, and dogs are from published studies although this analysis has not previously been published (Trevaskis et al., 2013).