Table 3.
Characteristics of the low and high IgG3 groups and low and high MFI groups at biopsy time.
| Patients with low IgG3 DSA (n = 35) | Patients with high IgG3 DSA (n = 34) | p-value | Patients with low MFI (n = 39) | Patients with high MFI (n = 30) | p-value | |
|---|---|---|---|---|---|---|
| DSA characteristics | ||||||
| iDSA Class | 0.99 | 0.002 | ||||
| iDSA class I | 9 (25.7) | 9 (26.5) | 16 (41) | 2 (6.7) | ||
| iDSA class II | 26 (74,3) | 25 (73,5) | 24 (59) | 28 (93.3) | ||
| MFI DSA | 6,000 [2,000–12,000] | 7,100 [4,225–19,380] | 0.39 | 4,000 [1,900–5,500] | 19,585 [10,770–21,360] | <0.0001 |
| Histological characteristics | ||||||
| g + cpt score, mean ± SD | 1.8 ± 1,7 | 3.2 ± 2.0 | 0.006 | 1.8 ± 1,5 | 3.3 ± 1.8 | 0.003 |
| i + t score, mean ± SD | 1.3 ± 1.6 | 1.5 ± 1.7 | 0.56 | 1.1 ± 1.5 | 1.8 ± 1.8 | 0.06 |
| v score, mean ± SD | 0.1 ± 0.5 | 0.1 ± 0.2 | 0.99 | 0.1 ± 0.2 | 0.1 ± 0.6 | 0.81 |
| cg score, mean ± SD | 0.2 ± 0.5 | 0.5 ± 0.9 | 0.08 | 0.1 ± 0.5 | 0.6 ± 0.8 | 0.002 |
| IF/TA score, mean ± SD | 1.3 ± 0.9 | 1.2 ± 0.8 | 0.85 | 1.1 ± 0.8 | 1.3 ± 0.8 | 0.29 |
| cv score, mean ± SD | 1.0 ± 0.6 | 1.8 ± 0.9 | <0.001 | 1.4 ± 0.8 | 1.3 ± 0.8 | 0.38 |
| C4d score, mean ± SD | 0.9 ± 1.3 | 1.6 ± 1.4 | 0.048 | 0.9 ± 1.2 | 1.8 ± 1.3 | 0.01 |
| Clinical characteristics | ||||||
| Serum creatinine (μmol/L) | 127 [107–178] | 151 [120–200] | 0.06 | 149 [114–203] | 145 [113–185] | 0.55 |
| eGFR MDRD (ml/min/1.73 m2) | 47 [38–64] | 44.5 [24–51.3] | 0.09 | 44 [28–56] | 48 [34–60] | 0.41 |
| PU/CU ratio (g/g) | 0.25 [0.10–0.42] | 0.41 [0.16–1.55] | 0.05 | 0.33 [0.16–0.90] | 0.21 [0.10–0.72] | 0.20 |
| Time post Tx (years) | 4.1 [1.0–7.1] | 7.7 [3.0–10.3] | 0.02 | 3.7 [0.9–7.9] | 6.9 [4.1–11.2] | 0.003 |
| ABMR status | <0.001 | 0.09 | ||||
| No ABMR, n (%) | 25 (65.7) | 6 (17.6) | 20 (51.3) | 9 (30) | ||
| ABMR rejection, n (%) | 12 (34.3) | 28 (82.4) | 19 (48.7) | 21 (70) | ||
| Subclinical ABMR, n (%) | 6 (17.1) | 10 (29.4) | 9 (23.1) | 7 (23.3) | ||
| Clinical ABMR, n (%) | 6 (17.1) | 18 (52.9) | 10 (25.6) | 14 (46.7) | ||
PU, proteinuria.
CU, creatininuria.
Time post Tx, time post-transplantation.