Table 4.

Patients and DSA characteristics associated with GFR decline.

	Univariate analysis				Multivariate analysis
Variables	HR	95% CI		p-value	HR	95% CI		p-value
Recipient sex (male)	0.48	0.23	1.03	0.059
Recipient age (years)	0.99	0.96	1.01	0.287
Donor age (years)	0.97	0.95	0.99	0.017
Donor type (living vs. deceased)	1.75	0.41	7.4	0.448
Cold ischemia time (h)	1.05	0.50	2.21	0.890
HLA mismatches	0.90	0.68	1.19	0.448
iDSA class (II vs. I)	0.73	0.33	1.60	0.432
DSA number	1.75	1.16	2.65	0.008	2.04	1.17	3.58	0.013
iDSA MFI (log)	2.18	0.91	5.2	0.079
DSA IgG3 (high vs. Low)	4.23	1.80	9.97	0.001	5.69	1.82	17.8	0.003
ATG induction	0.47	0.22	0.98	0.045
Corticosteroids	0.84	0.37	1.91	0.684
Tacrolimus	0.60	0.29	1.25	0.170
Cyclosporine	1.08	0.44	2.67	0.871
mTOR inhibitors	0.79	0.30	2.09	0.641
IMPDH inhibitors	1.60	0.38	6.77	0.521
GFR (ml/min/1.73 m2)	0.96	0.94	0.98	0.001	0.95	0.93	0.98	0.002
PU/CU (log g/g)	1.12	0.96	1.30	0.157
C4d score	1.77	1.30	2.40	0.001
g + cpt score	1.17	0.96	1.43	0.126
v score	0.77	0.26	2.23	0.625
i + t score	1.14	0.91	1.41	0.276
cg score	1.54	0.99	2.39	0.054
FIAT score	1.67	1.07	2.61	0.025

PU, proteinuria.

CU, creatininuria.

Time post Tx, time post-transplantation.