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. 2020 May 15;14:131. doi: 10.3389/fncel.2020.00131

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Copyright © 2020 Peng, Dai, Li, Liu, Wang, Du, Teng, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of Arid1a promotes RGC survival. (A) Timeline of the experimental procedures. (B) Representative images of flat whole-mount retina stained with anti-Tuj1 from uninjured (intact), injured control (AAV2-GFP, Arid1a-WT), and injured Arid1a^f/f mice (AAV2-Cre, Arid1a-cKO). Scale bar: 20 μm. (C) Quantification of RGC survival at 14 days post-crush, expressed as a percentage of the average number of Tuj1+ RGCs in the contralateral (intact) retina. **p < 0.01. n = 6 mice in each group. (D) Representative confocal images of CTB-labeled optic from Arid1a^f/f mice with intravitreal injection of AAV2-GFP or AAV2-Cre viruses. n = 6 mice in each group. The yellow lines indicate the nerve crush sites. Scale bar: 100 μm.