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. 2020 May 15;14:131. doi: 10.3389/fncel.2020.00131

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Copyright © 2020 Peng, Dai, Li, Liu, Wang, Du, Teng, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome dynamic changes of RGCs after Arid1a deletion. (A) Volcano plot of log₂ (fold-change) vs. –log₁₀ (P.adjust) representing gene expression changes between WT and Arid1a cKO RGCs. (B) Kyoto encyclopedia of genes and genomes (KEGG) analysis of these differentially expressed genes in (A), the terms with the five highest –log₁₀ (P.adjust) are shown as a bar plot. (C) Gene set enrichment analysis (GSEA)-KEGG pathway analysis of RNA-seq data. (D) The protein-protein interactions of differentially expressed genes, only the 30 genes with the highest degree (low values to dark colors) are shown in a circular layout.