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. 2020 May 15;14:131. doi: 10.3389/fncel.2020.00131

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Copyright © 2020 Peng, Dai, Li, Liu, Wang, Du, Teng, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The absence of Arid1a protects RGCs from apoptosis through regulating the expression of Socs3. (A) Venn diagram shows the overlap of genes with significantly reduced ATAC-seq signal at the promoter regions and genes with decreased expression in Arid1a deleted RGCs. (B) KEGG analysis of these overlapped genes in (A), two terms related to apoptosis (P.adjust < 0.05) are shown. (C) Genome-browser view at the Socs3 gene of different ATAC-seq data sets. Regions with a reduced ATAC-seq signal was highlighted in a brown background. (D) Statistical comparison of Socs3 expression before and after Arid1a deletion in injured RGCs. *P < 0.05. (E) The protein-protein interactions of different TFs which regulate Socs3 expression identifying with TRRUST. (F) Average profile showing differential footprinting of Sp1 at 4,660 sites.