Table 3.
Association of socioeconomic deprivation and cancer survival and adjusted 5-year observed survival estimates, overall with different levels of adjustment and stratified by patient and tumor characteristics with full adjustment.
| Subgroup (Modela) | Events [N (%)] | Deprivation quintile [Hazard ratio (95% confidence interval)] | 5-year survival (standard error)e | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Q1(least deprived) | Q2 | Q3 | Q4 | Q5 (most deprived) | Q1 (%) | Q5 (%) | Q5–Q1 (% units) | ||
| All (Basic model) | 19,227 (50.4) |
1.00 (ref) |
0.86 (0.82–0.90) |
0.97 (0.93–1.01) |
1.04 (0.99–1.09) |
1.08 (1.03–1.13) |
51.0 | 48.5 | −2.5 |
| All (+Stage) |
19,227 (50.4) |
1.00 (ref) |
0.90 (0.86–0.94) |
1.01 (0.96–1.05) |
1.04 (0.99–1.09) |
1.11 (1.06–1.16) |
51.7 | 49.0 | −2.7 |
| All (+ Surgery) |
19,227 (50.4) |
1.00 (ref) |
0.90 (0.86–0.95) |
1.01 (0.96–1.05) |
1.03 (0.99–1.08) |
1.11 (1.06–1.16) |
51.7 | 49.0 | −2.7 |
| Exclusion of Dresdenb | 15,023 (50.6) |
1.00 (ref) |
0.97 (0.92–1.03) |
1.03 (0.98–1.09) |
1.03 (0.98–1.08) |
1.11 (1.06–1.16) |
51.5 | 48.8 | −2.7 |
| Male | 11,101 (50.0) |
1.00 (ref) |
0.88 (0.83–0.94) |
1.00 (0.94–1.06) |
1.02 (0.96–1.08) |
1.10 (1.03–1.17) |
49.7 | 47.3 | −2.4 |
| Female | 8,126 (51.1) |
1.00 (ref) |
0.94 (0.87–1.01) |
1.03 (0.95–1.10) |
1.06 (0.98–1.15) |
1.13 (1.05–1.22) |
54.4 | 51.3 | −3.1 |
| Age 15–64 years | 4,456 (36.8) |
1.00 (ref) |
0.91 (0.83–1.00) |
0.96 (0.87–1.06) |
1.09 (0.99–1.20) |
1.16 (1.05–1.27) |
64.6 | 61.6 | −3.0 |
| Age 65+ years | 14,771 (56.8) |
1.00 (ref) |
0.90 (0.86–0.95) |
1.01 (0.96–1.07) |
1.02 (0.96–1.08) |
1.07 (1.01–1.13) |
45.2 | 43.2 | −2.0 |
| Period 2000–2007 | 11,615 (63.2) |
1.00 (ref) |
0.83 (0.78–0.88) |
1.01 (0.95–1.08) |
0.97 (0.91–1.03) |
1.05 (0.99–1.11) |
50.7 | 49.4 | −1.3 |
| Period 2008–2015 | 7,612 (38.6) |
1.00 (ref) |
1.03 (0.96–1.11) |
0.99 (0.92–1.06) |
1.13 (1.05–1.22) |
1.19 (1.11–1.28) |
53.1 | 48.5 | −4.6 |
| Colonc | 11,559 (50.4) |
1.00 (ref) |
0.88 (0.83–0.93) |
1.01 (0.95–1.07) |
0.99 (0.93–1.06) |
1.06 (1.00–1.13) |
52.8 | 51.2 | −1.6 |
| Rectumc | 7,201 (50.1) |
1.00 (ref) |
0.93 (0.86–1.01) |
1.02 (0.94–1.11) |
1.09 (1.01–1.18) |
1.18 (1.10–1.28) |
50.1 | 45.6 | −4.5 |
| Stage I | 2,706 (31.1) |
1.00 (ref) |
0.79 (0.69–0.89) |
0.98 (0.86–1.11) |
1.13 (0.99–1.28) |
1.18 (1.04–1.34) |
72.3 | 68.8 | −3.5 |
| Stage II | 4,166 (41.3) |
1.00 (ref) |
0.84 (0.76–0.92) |
0.89 (0.81–0.99) |
0.95 (0.86–1.05) |
1.12 (1.02–1.24) |
62.7 | 59.6 | −3.1 |
| Stage III | 4,791 (47.1) |
1.00 (ref) |
0.95 (0.86–1.04) |
1.11 (1.01–1.22) |
1.16 (1.05–1.27) |
1.12 (1.02–1.23) |
55.7 | 52.4 | −3.3 |
| Stage IV | 7,564 (82.3) |
1.00 (ref) |
0.96 (0.89–1.03) |
0.99 (0.92–1.07) |
0.96 (0.88–1.04) |
1.02 (0.95–1.10) |
13.8 | 13.2 | −0.6 |
| FU length: 3 monthsd | 2,426 (6.4) |
1.00 (ref) |
1.01 (0.89–1.15) |
1.11 (0.98–1.27) |
1.07 (0.94–1.22) |
1.07 (0.94–1.22) |
Na | Na | Na |
| FU length: 1 yeard | 6,503 (17.1) |
1.00 (ref) |
1.01 (0.93–1.09) |
1.03 (0.95–1.12) |
1.00 (0.92–1.08) |
1.03 (0.95–1.12) |
Na | Na | Na |
| FU length: 5 yearsd | 15,649 (41.0) |
1.00 (ref) |
0.97 (0.92–1.02) |
1.03 (0.98–1.09) |
1.03 (0.98–1.09) |
1.12 (1.06–1.17) |
52.4 | 49.6 | −2.8 |
| FU length: 10 yearsd | 18,630 (48.9) |
1.00 (ref) |
0.93 (0.89–0.98) |
1.01 (0.96–1.05) |
1.03 (0.98–1.08) |
1.11 (1.06–1.17) |
51.8 | 49.0 | −2.8 |
ref, Reference; Q, quintile; Na, not applicable as follow-up was restricted to <5 years; Significant hazard ratios (p < 0.05) are printed in bold;
for the overall analyses, three models were used. The basic model includes an adjustment for sex, age, period, cancer site and cancer grade. In the second model, stage and in the third model, surgery was added. In all stratified analyses, model three was used (after omitting the stratification factor).
the city Dresden was the largest city in the covered area, comprising 13.4% of the total underlying study population.
patients with a diagnosis of both colon and rectum cancer within 3 months were excluded. Rectum includes rectal (ICD-10 C20) and rectosigmoid (C19) tumors.
follow-up length was restricted to a certain time window. Patients dying after this time were censored at the end of the time window.
five-year overall survival derived from the direct adjusted survival curves from the adjusted Cox proportional hazard regression model.