FIGURE 5.

Result of RDB showing a result of normal individual will give positive results with each wild-type sequence but not with any mutant probe (upper panel). Heterozygotes show a reaction with a single mutation dot in addition to the normal dots (middle panel), whereas homozygotes will give a positive dot with that mutant probe but not with its corresponding normal sequence (two mutant dots will be seen if the individual carries two different mutations) together with positive spots for the remaining normal probes (lower panel).