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MACC1 induced by pro-inflammatory cytokines increases migration. MACC1-dependent cell migration was confirmed by stable MACC1 overexpression or MACC1 siRNA-mediated MACC1 down-regulation. Cells were treated with either TNF-α (A) of IFN-γ (B) for 24 h before cell migration was measured. Results are representative of at least four independent experiments. The data are presented as mean ± SEM with the statistical significance levels: **p ≤ 0.01; ***p ≤ 0.001 and ****p ≤ 0.0001.
